We have seen this at Ferret Wise on a 2 year old late alter ferret that was turned in w/o vaccination information. The rabies vaccine was administered ( for adoption purposes) and the ferret nearly died. Just moments after injection ( yes benedryl had been pre-treated) the ferret started vomiting first white foam then blood at the same time blood poured out the posterior end. The vet immediately injected epinephrine once, and then again and the ferret was ultimately near dead for another 2 hours. We finally left ( the ferret & myself) when it looked as if the ferret would survive. However it was almost 6 months before the ferret was eating right due to a hepatic condition which resulted. Anaphalaxis is VERY scary it also can leave a ferret with health impairments--- and we have never vaccinated a marginal ferret since that date for either rabies or distemper. Alicia www.ferretwise.org [Posted in FML issue 5161]