On the advice of my vet, I do pretreat before all their vaccinations. I start a couple days before the shots and I won't be stopping this. I have almost lost several of my babies over the years because we didn't pretreat and I agree that I would rather my kids be a little bit sleepier for a couple days than to die on me because of a reaction. I had one of my guys get the Purevax in 2003 and we had even pretreated since he was adrenal and having other issues and he had the worst reaction that my vet had ever seen, they were pretty sure that they were sending him home with me to die but I babied him all night with fluids and softened food and after a couple days he started eating again but this was even after preteating so there is no guarantee that pretreating will not stop a reaction but I take no chances. My babies are too special for me not to do everything in my power to help them as much as I and my vet can. So I will always pretreat whenever they go in for their shots. They had their shots yesterday and no problem, thank God!! And they weren't even sleepy! Vet said you couldn't tell they had been pretreated for a couple of days, they were still bouncing around like usual, go figure! Thanks for listening Julie [Posted in FML issue 5123]