Susan in UK, ferret adrenal growths tend to affect hormonal output (esp. estrogen) rather than output of cortisol, so Cushings approaches don't tend to be appropriate. (There are some unusual cases, and in those also watch for diabetes -- which is thought to be why Lupron can reduce or sometimes cure some cases of diabetes in ferrets.) See the FHL Archives under my name, also vet posts carried to the FML as "from FHL" posts, and http://www.miamiferret.org/fhc/adrenal.htm In the FHL archives especially look for adrenal posts from AFERRETVET. For what disorder is he on Pred? Pred is not useful for the type of adrenal disease ferrets tend to get, and it can be hard on a diseased heart. Does he also have insulinoma (which is an excellent reason to use Pred)? -- Sukie (not a vet) Ferret Health List co-moderator http://www.smartgroups.com/groups/ferrethealth FHL Archives fan http://ferrethealth.org/archive/ replacing http://fhl.sonic-weasel.org International Ferret Congress advisor http://www.ferretcongress.org [Posted in FML issue 5032]