This article will be very, very, very (Did I remember to say "very"?) useful for you: http://www.afip.org/ferrets/PDF/insulinoma.pdf and http://fhl.sonic-weasel.org will also help. Prednisolone tends to be more effective than Prednisone if there is also an liver damage (because Prednisone needs a liver processing steo to be turned into Prednisolone). Pred should be given with food twice a day (sometimes 3 times a day if the sugar balance becomes hard to maintain. To try Diazoxide (Proglycem generic) to see if it will help with your little one try a trial by using a compounding pharmacist used to ferrets. Many of them ship. You can find a list of such pharmacists in http://www.smartgroups.com/vault/ferrethealth/ReferenceShelf/ comp_pharm.html Surgery can be useful. There is a marvelous write-up on this surgery in Dr. Rosenthal's column in the latest issue of Ferrets Magazine. Sukie (not a vet) ***** Here is a very unexpected dietary research study result which I am sure will be looked at more carefully in further studies (which is -- of course -- exactly what needs doing before drawing conclusions based upon one study or upon the even weaker basis of a hypothesis) : ***** http://www.sciencenews.org/articles/20050611/food.asp ***** For those interested in microRNA and malignancy: ***** http://www.sciencenews.org/articles/20050611/fob1.asp [Posted in FML issue 4905]