See: http://www.smartgroups.com/message/viewdiscussion.cfm? gid=1423922&messageid=13515 Okay, first off, remember what melatonin is. Is is a compound which the body itself makes when it gets enough darkness. (The degree of darkness matters since even a little light can really decrease the production.) With your first ferret, Joni, it sounds like the adrenal disease really took off from at least one bit of tissue remaining behind and she developed the anemia complication which takes some adrenal ferrets. Dr. Jerry Murray has some marvelous past posts discussing this complication. See posts from AFERRETVET in http://fhl.sonic-weasel.org Rusty was being helped by the melatonin and you should consider also getting LUPRON DEPOT into him since you say that he isn't a surgical candidate, or if you are in Australia then Suprelorin is an option. Blade's low blood sugar: that could be from insulinoma (or more rarely a different pancreatic growth), or from his anorexia causing his sugar to drop, or both. There tends to be a reason behind anorexia and some of those can also cause extreme weakness, for instance lymphoma or cardiomyopathy and hypertrophic cardiomyopathy can be hard to spot too often. Since melatonin can cause some sleepiness that would make such limitations more noticable and give you a useful heads-up to do more tsting on this little one. Also see: http://www.miamiferret/fhc the FML Archives (The address is in the header of every day's FML the FHL Archives http://fhl.sonic-weasel.org So, basically: Joni had a well documented complication to adrenal disease and her symptoms showed that adrenal disease was still present. Rusty was being helped but needs to have a stronger approach and since he isn't a surgical candidate for unstated reasons that means Lupron Depot, too. Since he will continue to have an adrenal growth he will need regular evaluation so that if serious complications like anemia or prostate enlargement show up those can also be medicated for. Blade also needs a vet visits since he has something going on producing that anorexia and needs testing for possible causes of anorexia and possible causes of low blood sugar. Definitely time for a vet visit for those two. In Blade's case the tendency of melatonin to produce tiredness may make the poor coordination and weakness symptoms of underlying illness more apparent just as getting tired on his own would do. Melatonin has been tested in so very many ways in so very many ferrets and it repeatedly has minimal unwanted side effects. --- Amber, Gus is INCREDIBLE! So are you! I am so glad that you two have each other! --- Dani, RESTRICT HIS ACTIVITY FOR AT LEAST 10 DAYS AFTER MAJOR SURGERY! HE SHOULD NOT BE SCURRYING AROUND, HE SHOULD NOT BE WRESTLING. HE SHOULD NOT BE CLIMBING. Sorry, about shouting, but I had to make sure you would see this fast which is why I also copied it to you. A too common cause of post-surgical death is injury from too much activity too soon. [Posted in FML issue 4852]