Laraine, the lympho itself may be in either his adrenal, his pancreas or both, so he might actually have just one disease in multiple organs (so the symptoms would be of multiple diseases), or may have all three common medical problems simultaneously. How was the lympho diagnosed? Lymphoma can not be diagnosed by blood tests. That is something which was once long ago thought to be possible (and sadly got too much popular press as if it were proven before testing showed that it didn't work even though the hypothesis had looked promising) but actually infections also throw off the white count badly (in fact, one disease actually results in higher white counts than are seen with lympho; see the write-ups in http://www.miamiferret.org/fhc on mystery disease/DIM which has some attached divergent hypotheses and work advancing on two different approaches). Diagnosing lympho is based upon biopsies of a removed node, or sometimes on aspirates (which have a greater error risk in either direction), and at times the presentation is such that lymphoma/lymphosarcoma or carcinoma become very reliable postulated diagnoses even without biopsy confirmation. For a long time there were only a few ferrets doing very well with chemo approaches, but the number was small, and usually the best approach was to give Prednisolone, especially if the ferret was not in the prime of life. At six years of age your ferret is early-old so is past the prime of life years of 3 and 4. (Pediapred is a Prednisolone, BTW.) The reason Prednisolone makes more sense than Prednisone is because it skips the liver processing step where the body converts Prednisone into Prednisolone. If the liver is at all compromised (and with lympho it often is) the Predisone may be poorly utilized, but the Prednisolone will still work to improve quantity and quality of life. Alternative steroids are used for some ferrets or preferred in some locations. Ferrets are NOT prone to steroid side-effects so large amounts can be used usually, but it does make sense to give Pred with food and to use Carafate at a different time. Pred is usually given twice a day, sometimes three times a day. We personally have found that also using tiny amounts of opiate pain control also helps greatly with quality of life for some who have lympho. Usually we use Torb. Recently, there have been advances in chemo approaches for ferrets which people should know about. Yesterday a dear friend who goes to a highly reputable vet mentioned that he is using one of the new protocols (not the Tufts one) and is very pleased with it, plus is not seeing adverse reactions. I will copy this letter to my friend in case she has a chance to find out where your vet can get information on this new approach. Another of the new chemo approaches is one from Tufts which is all NON-IV. I have heard multiple very favorable reports from vets on this approach. Remember that these are new approaches so success rates are not known yet, but that early reports are certainly good. Your vet can contact Dr. Joerg Mayer at Tufts: < [log in to unmask]> to learn about the new Tufts protocol. Personally, with Prednisolone we have gotten as much as 14 months or as little as 6 months for lymphoma. If there is not a medication conflict your vet may want to use Lupron, Suprelorin, Melatonin implant, or a combo of one of the first two with the third to also help reduce the problems associated with the adrenal growth. To better understand lympho itself I suggest the Ferrets Magazine articles by Dr. Bruce Williams in http://www.afip.org/ferrets/index.html Some of the vets mentioned in this post will speak at the upcoming IFC Symposium in St. Louis, MO http://www.ferretcongress.org and some in Autumn's AFA conference http://www.ferret.org/ Sukie (not a vet) Co-moderator http://www.smartgroups.com/groups/ferrethealth Advisor IFC participant in several ferret health projects ferrets in the family for 24 years [Posted in FML issue 4832]