The latest data from the CDC is that the only definitive test for rabies is done post mortem from the brain tissue of the animal. As a pet, (which skunks can be and are!) He should have been held the 10 days rather than killed. I think it also depends on where you live, and the regs regarding if a skunk is considered a pet, an exotic pet, or a wild animal. If they had been licensed for taking in and caring for wildlife, again, it depends not only on state laws, but county/city as well. I would ask, if they have skunk pets, if they had been vaccinated against rabies? That alone would have saved his life, and they may want to consider that with any other poofers they have, or adopt in the future. Skunks are soooooooooo adorable, not in the ferrety sense, but such a personality... stubborn! If we lived in an area that did not allow ferrets, I'd have skunks..... Think our 13 +2 ferts would most vigorously object were we to bring BIG poofers into our home tho! Regarding the surgery vs lupron. Living in the state where a lot of new research has been done, the data so far shows that most (not all) ferrets regrow adrenal tumors within 1-2 years. The ferret-savvy Vets that are in contact with the Vet/researcher are actually no longer doing surgery for adrenal tumors, and are placing the ferts that are exhibiting lupron-sensitive symptomology immediately on lupron. Rather than starting at 100 mcgs / month, the new protocol is start at 200 mcgs, and go as high as 500 mcgs per month. We have a female that within 6 months after adrenal surgery, became symptomatic, and was placed on lupron... that was 3 years ago. She is now pushing 6, is blind, but still no return of the adrenal problems/symptoms, nor can the Vet palpate any growths. She has been on 200 mcgs per month, and we've not had to increase it. The other ferrets that we have on lupron have all become asymptomatic... 2 are also on pediapred for insulinoma, but so far, doing well, and dooking away! I realize that there are 'other' types of cancer that can be in the adrenal glands that do not respond to the lupron, but I do not know what the prognosis is for those specific types of cancer post operatively. There is also a trial study to see if giving non-adrenal ferrets 100mcgs of lupron in the Fall, and again in the Spring can actually keep the ferrets from becoming adrenal. We have 7 that are on the trial... and none of them are youngsters, so we shall see. Yes, lupron is pricey, but our babies are worth every penny, and we buy it in 'bulk' which reduces the cost per shot per month of 200 mcgs to around $12.00. Well, that's about it from Wild Weasel Rez and Wildlife Sanctuary, (Michelle) and to Wolfysluv... you go girl! [Posted in FML issue 4802]