Great topic. I'm a novice, only had ferrets for a tad over 5 years. In those 5 years I've acquired 6 ferrets. I've made decisions to cut, and not. I base my decision on two things, the opinion of my very knowledgeable vets as to the prognosis, and the overall health of the ferret. The Little Kidd, male age 2 1/2. Hair loss, slight weight loss, slightly lethargic. CBC values were as good as it gets, we opted for surgery. Left adrenal enlarged, removed, right slightly enlarged, frozen. That was two years ago, no further problems. The Kidd, male age 3. Insulinomic crash, started on pred for two months to stabilize glucose. This was a tough decision, but I opted for surgery due to his age, and the fact his CBC showed all functions were go. Also, my vet has had good results doing surgeries for insulinoma tumors. Several small cells removed, along with the left slightly enlarged adrenal, right looked fine. That was almost two years ago. If/when he has symptoms again, we will not do another surgery, but manage it with pred. Parris, female age 5. No health problems. I will base any future decisions on her overall health and the opinion of my vets. Buddy, age 6, Mz Lily, age 4?, Isabella, age 3? All shelter surrenders, bald and sick. All had immediate adrenal surgeries. Mz Lilly and Isabella are now healthy and have beautiful coats. Buddy has a nice full coat, but has one kidney, (one lost during surgery that took 110 minutes) cardiomyopathy and is now insulinomic. I opted for no further surgery, based on his age (6+), health, and the opinion of my two vets. He is maintaining well on meds. His surgery was almost a year ago. I just recently started all 6 on oral melatonin, am considering implants. Ardith [Posted in FML issue 4802]