Hello. My Mikette has been on meds for insulinoma for about a year and a half. She is currently on pedia pred and diaoxide. The last few weeks we've needed to raise the level twice and now a third time. Her BG has lowered quite a bit and her hind end has gotten weaker and she occasionally gets tremors. She gets her meds twice a day, about 12 hours apart. I was wondering if possibly the problem isn't so much the amount of meds, but the time apart in the distribution of them. Has anyone found that they need to give insulinoma meds more often than twice a day. I'm thinking possibly that her body drops it's level too fast and she needs them again in that 12 hour period. I will be calling my vet today, but I would love to get some input with those of you that have had more experience than me. Thanks Risa [Posted in FML issue 4758]