[Sukie Note: Dr. Murray had the sort of typo we all make: in the first sentence read "lymphoma" instead of "insulinoma" for it to fit his subject line and content.] http://www.smartgroups.com/message/viewdiscussion.cfm? GID=1423922&messageid=11867 There are basically 3 treatment options for ferrets with insulinoma. 1) is chemotherapy. This is usually a multiple drug therapy with L-asparaginase, cyclophosphamide; and pred; or vincristine, cyclophosphamide, methotrexate, L-asparaginase, and pred; or vincristine, L-asparaginase, cyclophosphamide, doxorubicin, and pred; or L-asparaginase, vincristine, cyclophosphamide, and pred. There is also a chemo therapy using oral and SQ injections that Tufts University is working with that uses pred, L-asparaginase, cyclophosphamide, cytarabine, methotrexate, chlorabucil, and procarabazine. 2) less aggresive chemo with pediapred and cyclophosphamide (cytoxan). Both of these are giving orally!! 3) palliative treatment with just oral pediapred. In addition a high protein, high fat, low carbohydrate diet helps (baby food, Hill's a/d, Pretty Pets Natural Gold for Ferrets,etc.) Lymphoma uses simple sugars to grow, thus a low carbohydrate diet helps "starve the cancer." Fish oil supplements also help. Antioxidants like vit E and melatonin may also help. Unfortunately lymphoma is usually a fatal disease regardless of what treatment option is used. Hope that helps, Jerry Murray, DVM [Posted in FML issue 4730]