Hi, Ann, and everyone else, Your situation, or ones like it, are all too familiar. I think our vet would, like yours, get the ferret stronger so that she'd be a better surgical candidate. He'd probably go after the pancreatic mass and whichever adrenal gland is most urgent first, then let her recover and rebuild her strength for six to eight weeks, and then go after the second gland. When he did the right he'd ligate the vena cava. I've had one ferret, Lady Ayeka, go through combined insulinoma/adrenal surgery like that (left gland) and she came through with flying colors. I've had three ferrets have their right gland removed with vena cava ligation and all came through just fine. Podo was seven and a half when he had his right out and lived to be just about 10. The reason for separating the two surgeries is that the combined surgery is rough enough on the ferrets and when our vet did bilateral adrenal surgery and possibly insulunoma surgery all at once his success rate dropped. It was just too much for some ferrets. When the second adrenal gland comes out that will be an even rougher recovery. If the starting dosage of medications to replace the missing adrenal products the ferret will start showing symptoms of surgically induced Addison's Disease. We had that with both Pertwee and Ryo-Ohki. Once the medications were right and their electrolytew were in balance and, in Pertwee's case, another medical issue was dealt with, they rallied. Make sure you educate yourself about Addison's after bilateral adrenalectomies and expecially about how to recognize an Addisonian Crisis, which is life threatening. The Ferret Health List archives have tons of great material. You can find them at http://fhl.sonic-weasel.org I'd also recommend subscribing to the FHL if you don't already. The more you know the better you can recognize potential problems that may need immediate vet care. I wish you and your little one the best of luck. Pertwee lived for almost four years with no adrenal glands and was our most crazy, frenetic, and absolutely wired weasel pretty much that whole time. The usual disclaimer applies: I am not a vet. I just have been where you are now. All the best, Caity and the fantastic four [Posted in FML issue 4714]