http://www.smartgroups.com/message/readmessage.cfm? gid=1423922&messageid=11523&startid=11518 Hi all, Mike and Sukie were right again! 1. Most ferrets will respond to doses below 500 mcg/kg/month. Roughly 80% will respond to 100 mcg and another 10% will respond to higher doses (200-500 mcg). Unfortunately ~10% do not respond to Lupron. There is certainty no danger with starting with a high dose if you would like to. The only problem is cost. 2. It does not make sense to give Lupron only when signs return. The once a month version only lasts for 4-5 weeks, so all the time after that, you are letting the adrenal gland be stimulated and hormone levels elevate and giving the adrenal gland time to enlarge. These bad things are happening while you are waiting for signs to return. Thus it makes more sense to give monthly!! Hope that helps, Jerry Murray, DVM http://www.smartgroups.com/message/readmessage.cfm? gid=1423922&messageid=11524&startid=11518 Regardless of the type of tumor (and especially if it is malignant) I would recommend Lupron if all of the right gland can not be removed. The part of the adrenal gland that remains will likely become a problem again, so giving Lupron to try to prevent a future reoccurrence of the tumor makes sense. Hope that helps, Jerry Murray, DVM [Posted in FML issue 4703]