Lupron is one of the drugs which is used in treating existing adrenal disease. Often it will be used in conjunction with melatonin. When there are certain complications other meds amy also be needed such as Proscar/Propecia for prostate enlargement which seems to be by far the most common life-threatening complication. FML members can see by reading up on adrenal disease that there are many reasons why surgery is usually the best bet for adrenal disease. Prednisolone/Prednisone is not useful for treating adrenal disease, but you will find it used for one problem related to adrenal disease which can happen. Prednisolone/Prednisone is used to treat Addison's which develops if the adrenals are completely removed. (Note the word "completely" because many vets wind up leaving a bit behind.) or if the adrenals cease functioning (Sometimes when one is diseased the other will be suppressed temporarily or less often may atrophy, and Lysodren which has been mostly abandoned for treatment of adrenal disease also sometimes causes adrenal atrophy and can thus be suddenly fatal, whereas other times Lysdoren just doesn't work at all.) Prednisolone/Prednsione is typically used in conjunction with either Percorten or Florinef/Fludrocort when it is needed for this use. When that mix of drugs is needed it is absolutely essential fort survival. You see, some adrenal products help the body maintain the correct amounts and proportions of electrolytes which are needed for cell function and survival, and some also are needed for the body to maintain proper hydration. You can see why lacking them is fatal. Now, on very, very, very rare occasions people have had ferrets who have had surgery on both adrenal of a ferret and the ferret continues to need the drugs which help avoid Addisons Crises, but they have never-the-less begun to overproduce hormones as with normal adrenal disease. In those ferrets it is thought that the sections which were left behind are able top produce hormones but not the steroidal products of the adrenal, hence the need for meds to tackle both in those rare individuals. So, to sum up: you are asking about drugs which are needed for two DIFFERENT things. Neither can be used to replace the other. [Posted in FML issue 4673]