I looked this up on the internet and I can understand why it was taken off the US Market. If you want to order it, the only way is thru the Canadian Pharmacy on the internet. I don't have that site. BIG, if this is to be big to in on the FML let me know. Thank You Marie and her 5 Most Wonderful Fur Kidlets (Ferret Nanny on the 22 Aug, 3 more coming in, until June 30th 2005) [Moderator's note: Looks like it just squeezed through the size limit. Material from nih.gov can be reproduced here, so that's fine too. BIG] http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202577.html Description Trilostane ( TRYE-loe-stane) is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland. This product was withdrawn from the U.S. market in April 1994.Other medical problems The presence of other medical problems may affect the use of trilostane. Make sure you tell your doctor if you have any other medical problems, especially: Infection or Injury (recent serious) Trilostane may weaken the body's normal defenses Kidney disease Liver disease Precautions While Using This Medicine It is very important that your doctor check your progress at regular visits to make sure that trilostane is working properly and does not cause unwanted effects. Check with your doctor right away if you get an injury, infection, or illness of any kind. This medicine may weaken your body's normal defenses. Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking trilostane. Your doctor may want you to carry a medical identification card or wear a bracelet stating that you are taking this medicine. Side Effects of This Medicine Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Rare Darkening of skin; drowsiness or tiredness ; loss of appetite; mental depression; skin rash; vomiting Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your health care professional if any of the following side effects continue or are bothersome: More common Diarrhea; stomach pain or cramps Less common Aching muscles; belching or bloating ; burning mouth or nose; dizziness or lightheadedness; fever; flushing; headache; increase in salivation; nausea; watery eyes Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. Revised: 10/16/2000 Micromedex, Inc. Disclaimer http://www.axiomvetlab.com/EF%202-1.html Trilostane Treatment in Canine Cushing's Syndrome Summary Spontaneous hyperadrenocorticism (Cushing's) is a common clinical syndrome in dogs, resulting from excessive circulating cortisol concentrations. This is usually caused by an ACTH secreting pituitary tumour (85% of cases) but occasionally results from an adrenal gland tumour. Recently "Vetoryl" (active drug: trilostane) has been licensed for treatment of canine Cushing's disease. Trilostane blocks the normal adrenal steroidogenesis pathways, causing a reduction in circulating hormone concentrations in many affected cases. Unlike mitotane, Trilostane is given daily for life. Initial starting dose varies but a common daily starting dose is approximately 60 mg (dogs between 5-20kg), 120mg (dogs between 20-40kg) and 120-240mg (dogs >40kg). Monitoring should consist of: Clinical evaluation within 2-4 weeks ACTH stimulation testing: perform 4 hours after giving that day's Vetoryl medication Vetoryl Monitoring Protocol Collect fasted whole blood sample four hours after giving Vetoryl Administer 250mg ACTH (Synacthen) intramuscularly Collect second whole blood sample one hour later Label tubes "pre" and "post" accordingly Submit to Axiom and indicate that dog is receiving Trilostane therapy Results and full interpretation will be available on the day of receipt (Mon-Fri) If required, endocrine staff will be available to discuss the case further at no extra charge Further Information For further information on canine hyperadrenocorticism or Trilostane therapy in particular please feel free to call Axiom where one of the veterinary clinical pathologists will be happy to help. Alternatively the following references may be of interest: Neiger, R. and Hurley, K. (2000) Long term efficacy and safety of trilostane for treatment of canine hyperadrenocorticism, Journal of Veterinary Internal Medicine, 124, 376 Neiger, R. and Hurley, K. (2001) 24 Hour cortisol values in dogs with hyperadrenocorticism on trilostane. Proceedings of the BSAVA congress, Birmingham, p549. Hurley, K.J. (1998) Trilostane in the treatment of canine hyperadrenocorticism. ESVIM congress, Vienna [Posted in FML issue 4607]