Hello. I know the depot and 24 hour lupron was just discussed recently, when I try to access the archives my system shorts out. I recall the 24hour once a month lupron being recommended, and the depot form being warned about since it needed to be used immediately after mixing. My little Mikette (well, not so little with the huge pred belly!) has troubles again. She now has left adrenal problems and just got her first Lupron shot. The vet used the depot form but it was frozen, they thawed it in the syringe while we were there. She said it is a time release form and Mikette will get the shot once a month. Anyone have any knowledge of this form? I was wondering about it's effectiveness after being frozen. Thanks Risa [Posted in FML issue 4592]