I have had reactions to both Fervac-D and Purevax. The last two reactions I had were to Purevax and they were worse than any I ever had with Fervac, both ferrets took a couple of days to recover and become themselves again, with the Fervac they were back to normal in a few hours. I also had a ferret have a reaction to the Benadryl. He was pretreated before his distemper shot and within 10 minutes of giving him the Benadryl he was throwing up blood and had diarrhea, shortly after that he collapsed. He did not get his shot that day and we have determined he is allergic to Benadryl. I've now had three ferrets do this so I'm a little leery of pre-treating if they haven't had a reaction in the past. Anybody else see this happen? Kay [Posted in FML issue 4569]