Dear Northern I just went through this with a bonded pair of shelter ferrets. Stryder and Alluria were an old pair of ferrets (he was 6.5, she was 6)- and Stryder had a sudden seizure later found to be because of a blood clot. I had him put to sleep that Friday. Saturday found Alluria completely lethargic, wouldn't eat and looked very dull and listless. I started her on sub-q fluids, force feedings (just a simple mix of A/D and baby food) and carafate to protect her stomach. On Monday when I took her to the vet, they could find absolutely nothing wrong with her - her blood tests, including chemistry came back perfect, the exam found no reasons for her to be this way - but she had lost 200g of weight. The vet listed "death of cagemate" as the probable cause for her anorexia. It took me 10 days of feedings, fluids and meds before I was able to convince her to not leave. She is fine now - her weight is back up to normal and she is eating and drinking normally. She does not have a new cagemate - she was always aggressive around other ferrets. I will also comment that perhaps adding Tootsie may also be a factor - that Spunky is stressed not only because of the loss, but also because of the new addition. You might consider separating them for a bit until Spunky is back to eating/drinking again - not only to reduce her stress, but to also be able to monitor her food intake. If there is anything that I can do to help, please let me know..and I hope that Spunky will recover soon. Lisa Leidig, Head Ferret Shelter Wench in good standing The Ferret Haven "By-the-Sea" www.ferrethaven.org [Posted in FML issue 4562]