I read Mike's account of the ferrets that went into surgery after switching from the depot to the 24 hour lupron. Thank you Mike for posting more info on the situation. We had a similar experience with the 4 month depot. When I purchased the 4 mo depot for our group of 4 and it didn't work for them, a month later they were in surgery which resulted in one death. At the time I was understandably upset and Larry contacted Professional Arts. He was told they had no record of any other ferrets not responding to the depot form. That was the last time I ordered the depot form. I've been using the 24 hour lupron, given once a month for ferrets that aren't surgical candidates in our group. It's extremely important to report negative or lack of results of any drug to the manufacturer and vets. The 24 hour lupron has been available since 1999 and Larry has treated hundreds of ferrets with it. I've visited with him about making it clear that it is the 24 hour lupron so hopefully that will be helpful when it is ordered. My understanding is: 1. Once the depot form is mixed it has to be used immediately or be kept frozen in liquid nitrogen. Any lupron that is received pre-mixed would indicate to me it isn't the depot form. Please keep this in mind. 2. Lupron works for only so long, then it quits working so even though it can be helpful at the time, alternatives should be discussed for future treatment. I'm researching data on lupron and found interesting bits of information. I've not got the studies here with me so I don't want to quote without the references at hand but stay tuned for forth coming information. I've got about 500 pages of data to read through and pull references from so hopefully we'll all be more informed after I get through this. If anyone has references that would be helpful please email them to me. Some of the articles only mention lupron (not depot) so some time is spent contacting the authors to find out which form of lupron was used. And I'm trying to work this in during a very busy 'work' season. hugs to all. tle Troy Lynn Eckart, F.B.S. Ferret Family Services http://www.ferretfamilyservices.org http://www-personal.ksu.edu/~sprite/ffs.html http://www.geocities.com/Petsburgh/Haven/5481/ Please sign up to support our efforts http://www.iGive.com/FFS [Posted in FML issue 4566]