I'm glad someone else brought this up, because I was thinking possible lead poisoning. It can cause anything from lack of appetite to severe convulsions, and eventually death. I'm not sure if a tox screen could tell if this is the cause, so I would ask the vet to do a blood test specifically for lead. They can do that for humans - - and I see no reason why it can't be done for ferrets as well. In the meantime, please check out your ferret's food dishes. Change them out if you suspect them. Also, make sure the paint in your home is lead-free. There are still some older homes out there with leaded paint. I saw a few cases of poisoning in children while practicing as a paramedic. Make absolutely sure your ferrets couldn't have gotten into any medication. My little "angels" figured out how to get into our medicine chest, and scared me half to death! I've got a pretty unique group of Houdinis and petty thieves, causing me to realize a long time ago that ferret-proofing is an ongoing process. I hope the babies improve soon. More importantly, I hope a cause is found quickly. I know you're frightened. Sincerely - Jenny [Posted in FML issue 4490]