We almost lost a ferret who had an anaphalytic (sp?) reaction after receiving a dose of Advantage (to the back of his neck). Advantage was given Thursday morning. Two hours later we noticed that he was extremely agitated, bitting and clawing at his cage door and bleeding from his mouth and paws. Nose, gums and paw pads were bright red. Vet instructions were to give an injection of benadryl and within 10 minutes his color and activity was back to normal. We then bathed him to get the rest of the Advantage residue off. Since then he's had another 6 episodes into Friday, not quite as bad as the first, but we're constantly checking him so that we are probably catching these episodes sooner than we caught the first one. The only reactions to Advantage that I recall have been skin irritation. Has anyone else, see this type of reaction to Advantage? It's been such a good, quick and I thought safe way to eliminate fleas, that I hate to stop using/recommending it unless there's been other episodes like this one. Sandi Best Little Rabbit, Rodent & Ferret House a non-profit animal shelter 14317 Lake City Way NE Seattle, WA 98125 (206)365-9105 Open 6 days/week (closed Tue) or visit our on-line store at: http://www.rabbitrodentferret.org [Posted in FML issue 4430]