Well on this subject I can honestly say I have tried it and it did not work. I stick to the Advantage and Frontline. Also those wipes they give with the bio spot do not do a darn thing. If you look on Ebay you can get the Advantage and Frontline cheaper than a vet or that pet store on line. Just from my experience I am speaking. Sorry to those of you that have lost a fuzzie. Just remember the good memories that they leave with you. Trina and her crew of 10 fuzzies in Florida [Posted in FML issue 4342]