Hi Emily, I have had several ferrets who were not descented. The only difference is occasionally during play or sleep, they let go with some smell. Now mind you, it is nasty but goes away quickly. Just a few minutes and no more smell. Poofing is just an occasional thing. Not everyday. So I honestly wouldn't worry about it. BTW, each ferret also has a different poofy smell. I always know who it is. Lol. Blessings, Maggie [Posted in FML issue 4239]