Barb, a person almost never hears of anyone trying Lysodren for this anymore. A lot of times it does nothing, but when it does work it can sometimes cause atrophy and resulting Addisons. It's too unpredictable and sometimes too extreme. Usually the approach is surgery and then that isn't possible it most commonly now is Lupron, or Lupron and melatonin. There is a lot on these in these two Archives: http://listserv.cuny.edu/archives/ferret-search.html http://fhl.sonic-weasel.org/ and in great links available in the Critical Refs at http://www.ferretcongress.org With a secondary infection you have to consider that it might have started a stump pyometra (I can never be sure of the spelling on that so check spelling alternatives if that doesn't come up when you search on it/) in which case that also points to looking more carefully at surgery. Meanwhile, you may find that Zenodyne on a moistened swab may help. Disclaimer: I am not a vet. [Posted in FML issue 4143]