Hi Jennifer, My heart just breaks for you. I wish I could tell you a definite sign to look for, but I dont think there are any. I've yet to lose a ferret where it was a long time coming, but I've got a boy who is constantly loosing weight, having to be hand fed, perking up, etc. I know that the day will come when he wont perk up and I dread having to make that decision. You and CJ are in my thoughts today. Please keep us updated on how he's doing. ~Becky and Heather and the Magnificent 7 [Posted in FML issue 4106]