No one knows how long over a year the vaccines used for ferrets last. All that is know is that they do last at least a year. How long they last in other species doesn't matter, BTW. An example of why can be found in the studies when existing rabies vaccines were tested in ferrets, of those that worked (one well which is the Imrab 3 we use today, one with a huge amount of bad side effects and those ferrets were adopted by the testing vet and her workers so went on to be loved through their lives) was a vaccine that normally lasts a decent time in other animals. In ferrets it provided only 6 months of protection despite providing long protection for other species. I do recall a situation around here where someone was talked into trying an alternative med non-vaccine "vaccine". She went about life normally (rather that just being more careful like most of us are when we have one(s) who can't be vaccinated) and the ferrets became infected. The kits who had never had vaccines all died. The older ferrets had been vaccinated something like 3 (?) years before and I think 3 (?) of those survived but the survivors had permanent damage. It should be in the archives somewhere. Melatonin helps control symptoms of adrenal neoplasia and it may reduce the onset of hormonally related malignancies but I know of no other use for it. Your bit of a description that I recall is not consistent with adrenal neoplasia unless there are other things that you wrote which I completely missed (entirely possible) and even then what I recall of what you said would point to other things and the meds mentioned are not consistent with adrenal problems either. Actually, I can't offhand think of anything that medication combo is consistent with (for whatever that is worth or not worth). Could you describe what is going on? Diagnosis or tentative diagnosis and how it was arrived at? Yesterday you made a mention of there being a malignancy but I do not recall you going into what or the symptoms. Guess I missed something you wrote. BTW, although they should come out except when not possible most adrenal growths are not malignant so are not cancer and even a number of the adenocarcinomas that come out do not spread. It strikes me that there may be some confusion which could be dispelled by an old FHL post originally from 2001 which has last been run here in November of 2002. It is a Dr. Bruce Williams one on what is and what is not "cancer". Look for it at the bottom of the FML today if Bill puts the FHL stuff in their normal location (so that those who copy them can pick up any easily in one sweep). [Posted in FML issue 4118]