http://www.smartgroups.com/message/readmessage.cfm?gid=1423922&messageid=3285 The real question is what dose of Lupron are you using? If she has not responded after 3 months then it is likely that she will need a higher dose of Lupron (200-500 mcg/kg). The other option that can be used with Lupron is melatonin. 1 mg of the tablet or liquid version is giving once a day about 8-9 hours after sunrise. Another option is the mink melatonin implant that last for about 4 months. Hope that helps, Jerry Murray, DVM http://www.smartgroups.com/message/readmessage.cfm?gid=1423922&messageid=3286 Ovaban is megestrol acetate. It is a potent oral progestogen with anti-estrogenic properties. Side effects include mammary enlargement, listlessness, and possible diabetes and mammary cancer. For an adrenal male with prostate, high dose Lupron and Propecia is the better option. Lupron stops the stimulation to the adrenal glands and lowers the hormones they are producing. Propecia stops the formation of DHT. DHT is what causes the prostate to enlarge. A lot of these cases will also need an antibiotic (Baytril and/or Clavamox) for a long time to clear up the bacterial infection. Hope that helps, Jerry Murray, DVM [Posted in FML issue 4060]