A much more common cause of this than bladder stones is prostate enlargement secondary to the hormonal problems of adrenal gland disease. http://www.smartgroups.com/vault/ferrethealth/prostate.txt wil be helpful for you but incase you aren't at your computer right now I will copy the text to you privately because the sit4e is due to go down for 2 days for maintenance. Meanwhile, you will find a number of helpful posts at the FHL Complete Archives which will be up: http://fhl.sonic-weasel.org/ Of course, you can also find info on a number of other health problems in those archives, including bladder stones, corrective surgery, etc.. They have almost 2 years worth of posts by ferret vets and many who are used to ferrets' health problems and it is very easily searched archive. You should also be able to find useful posts on such topics by using the FML Archive (See FML header for addy.) which is also easily searched. Both are well designed and friendly resources. I use them a lot. Yes, with corrective surgery by a ferret knowledgeable vet adrenal neoplasia is far from fatal. Even one of the forms of malignancies they can get there usually is not with rapid surgery. The chance of a second adrenal also going up is something like 15% to 20%. There are possible things under testing to try to reduce the onset including: providing enough hours of complete darkness, giving melatonin, or giving Lupron. Important note: Ferret do cost a lot medically to maintain. That is one of the essentials of ferrets. For those who are insured from kithood there is insurance which can help, but for older ones the insurance company is often reported as not paying out. Saving for medical needs is ESSENTIAL when one has a ferret or three. Surgery is likely to be needed, especially for adrenal neoplasia, insulinoma, or both, and possibly for other needs. This is just a fact of ferrets. I know that for some this info comes too late or wasn't noticed other times when so many have said it, but maybe someone else whose ferrets can benefit from it will notice it this time around, so in case it helps someone it is here again. There is a lot of GOOD ferret medical info out there which is written by vets. One quick way to connect to many of these resources is to follow the links in the Critical Resources at http://www.ferretcongress.org . Of course, NOTHING replaces good hands-on care by a vet who knows ferrets. (And when vets don't know ferrets resources like Dr. Debbie Kemmerer's tapes which Mike told about yesterday -- Send GET FERRET 4033 to <[log in to unmask]> to get that issue -- the tapes of Charlie Weiss who is also a vet, and vet texts such as those by Doctors Karen Purcell, Cathy Quesenberry, Liz Hillyer, or James Fox are treasures for learning as well as confirming. There are also vets who ask questions on the FHL as well as those who answer them.) [Posted in FML issue 4034]