Hi First off, thanks for your advice on VanGuard 7. I am trying to find alternatives but few drugs are licenced for ferrets in the UK and I cannot get hold of the vaccines that I have used in the past. For those who were worried, the vet was prevented from administering the vaccine. In response to Amy, I too have had little joy in finding evidence to support annual vaccination. I live in an area in which diseases such as distemper are not uncommon. This is in part due to a large number of strays and the fact that canine vaccination is often avoided for financial reasons. I lost my first ferret because I was told by a vet that I was wrong to worry about hyper-oestrogenic shock. Since then I have refused to do what a vets says just because they say it. I too would be keen to hear arguments for and against annual vaccination from both professional and experienced subscribers. W. Wayne Gardner Clinical Scientist Dept. of Medical Physics Bradford Royal Infirmary [Posted in FML issue 4028]