Just a few of the problems with the rapid dismissals are: 1. totally missed alternatives such as the viral trigger hypothesis favored as a decent hypothesis (but not a fact) by some research vets for adrenal neoplasias, 2. forgetting that cure-alls historically do not pan out, 3. ignoring the fact that for some things it is thought that components may act additively or multiplicatively. For example, it is thought that it may be that a combination of early altering combined with another factor(s) might influence adrenal neoplasia rates (Note the qualifier since we are all discussing merely hypotheses rather than proven facts, though hypotheses are important.). Here's an example: In relation to that postulated century of barns with lots of ferrets and without true darkness that Bob mentioned, never forget that such conditions were and still are rare. For one thing the animals in such conditions were and are breeders, i.e. they have working gonads so that alone prevents generalizing from them to neutered ferrets. For another, the typical breeders found in the fur industry, research supply industry and pet industry -- are younger than most ferrets are at the on-set of most of the common ferret health problems. After peak breeding years most of such large places adopt out the ferrets, give them to shelters with donations to accompany them (a type of program which began years back in some places due to the efforts of several FML members), donate them to veterinary school programs to teach veterinary students how to sterilize ferrets, etc. After these peak years is also when the most common ferret illnesses start, but if the places don't have many animals of those ages... Can you count on one hand the number of such large farms which have released disease rates or details? Okay, can you count on one finger the number of such large farms which have released disease rates or details? So, what makes anyone think that some of these problems may not have existed in the individuals there? Anyone ever note that green and blue lights are especially bad for the body's natural melatonin production and that the green lights that are so omnipresent on electrical electrical equipment and night lights arrived about 12 to 15 years ago? There is more but this is just getting to be a frustrating waste of my time. Sorry to be blunt. I like the discussion of hypotheses, but to dismiss alternative hypotheses out of hand or to claim to have an actual answer is potentially dangerous for those few who panic or who try things without first checking with their ferret health care experts: the vets. Besides, I think that most folks are responsible and therefore instead of just trying things that might have negative health consequences I think that most folks here DO discuss such alternative FIRST with their vets and some even copy such discussions to their vets. Then they try them IF the vet says it's okay, or they try modifications which the vet may suggest, or they wait to see what happens with many others and what is reported in the veterinary journals if their vets feel that is safest. Therefore, since I see no reason to underestimate the logic of most FHL members I see no reason to go into details which so many of us know already such as the details above. I just don't have the time for this. [Posted in FML issue 3967]