Wowser! My email box was struck by lightning, or so it seems. Actually, in a single day, I have recieved some 90+ questions, comments, angry shouts, and pleas for more information regarding the first two installments of the ad libitum series. Be patient. This is a very complex area of study, and not even the scientists directly investigating the issue have all the answers, especially regardng the exact mechanisms describing how it works. I will be going through this very slowly, not because I think none of you can understand, it, but because if I take slow, carefull steps, I am less likely to fall on my face. I have a lot of training and experience in most of the areas being discussed, but, the literature I am sharing comes from such a wide range of interests and study that I have to be careful that I understand it well enough to explain it properly. For example, I have a single, important paper that forces me to review issues of individual gene extression, ageing, biochemistry, immunology, exercise, and the much beloved population genetics. I thought I would have to put a ruler on the page and go through it line by line. I could just read the results and tell you what they say, but I couldn't intelligently discuss the issues if I did. If I can't intelligently discuss the issues, then I can't tell you if they are applicable to ferrets or not. Bear in mind, I am sharing the information found in literally over a hundred information-dense references that are setting on my desk as I write. I don't think my brain will burn out, but it may dim the light bulb. So, I will take it slow and easy, and intelligently discuss enough of the issues over the next week so most, if not all, of your questions will be answered. My ignoring questions at this time should NOT be considered evasive, but rather a tactic to get through a complete explanation without being sidetracked. When I think I have finished, I will happy to field ALL remaining questions. Bob C [Posted in FML issue 3952]