http://www.smartgroups.com/message/readmessage.cfm?gid=1423922&messageid=1929 I will have to agree with the others. Yes, it still sounds like adrenal gland disease. Yes, a portion of the adrenal gland (1/3) can and does "regrow." Thus the tumor and signs continue or return. There are 2 basic options at this point. Surgery to remove the right adrenal gland completely. If the entire gland is removed then he will need hormone therapy (pred, percorten-V). Option 2 is to use Lupron to control the signs; however, sexual behavior is usually caused from adenocarcinomas. Those are the tumors that can get really big in size, so removal is the best option. Most right glands can be removed and the vena cava repaired, so vena cava ligation is still a last resort option. The surgery I did on Friday required vena cava ligation, but vena cava ligation should be reserved for those cases when the vena cava is damaged beyond repair. Hope that helps, Jerry Murray, DVM Dallas Texas. [Quick Sukie note: another common medical approach to lack of adrenal glands and Addison's crisis is the combo of Florinef and Pred.] [Posted in FML issue 3944]