http://www.smartgroups.com/message/readmessage.cfm?gid=1423922&messageid=1018 Yes the kidney can have cancer. Kidney (renal) cancer is rare, but they are usually very large in size. In my experience most are renal carcinomas (ie bad news). I had one like you described where I thought it was a very large adrenal gland, only to find out it was the enlarged kidney that I was palpating. Unfortunately renal carcinomas can spread to other organs such as the lungs. Lymphoma can also spread to the kidneys. With an enlarged spleen, lymphoma is a good possibility. As for the blood substitute (Oxyglobin), it is a cow based product, but it is safe to use in dogs, cats, and ferrets (birds, reptiles, and many zoo species too). Hopefully the pathology report will give you some good news and a good prognosis for Griffin. Jerry Murray, DVM [Posted in FML issue 3898]