I live in the Ft. Lauderdale, Florida area, my vet, who is an avian and exotic only vet, pretreats my ferrets for rabies and distemper with 1ml of benadryl. They wait about 15 minutes then give the shot. I like that she takes that precaution across the board, it makes me feel safer. She charges $13.00 for distemper $11.00 for rabies nothing extra for Benadryl. Angela (minky and pandora...patoooey--Bendadryl looks better on your shirt than in my tummy) [Posted in FML issue 3915]