With regard to Lupron my understanding is this: thing about adrenal disease is that as often as not, it's not actually a disease of the adrenal, but of upstream control of the adrenal. When that is the case, surgery may temporarily alleviate symptoms, but they will probably return, because the actual problem was not addressed. So, if the symptoms of adrenal problems aren't too severe yet, trying Lupron first could save your ferret the trouble and you the expense of the surgery. If the ferret doesn't respond to Lupron, then I'd guess it -is- truly an adrenal problem, and surgery might be needed. My friend John (he's a post-doc at Yale now) wrote an article about how Lupron works. It explains the guts of the science but in a way that non-molecular biologists can understand. Here's the link: http://www.miamiferret.org/fhc/lupron.htm Jen [Posted in FML issue 3891]