Some rare ferrets don't respond as well as normal or Prednisone, some other few are that way with Proglycem, and a few don't with either. She might be one of those individuals and need to have Proglycem added or to get that surgery sooner than you'd thought, or she might not be getting enough Pred. How much is she getting in milligrams? We have had a small female on as high as 5 full milligrams a day, but that is usually high. The Pediapreds come in 1 mg/ml and 2 mg/ml concentrations, if memory serves. Vets who are not used to ferrets very often give way too little Pred because they don't know the dosing for ferrets and they expect them to be more prone to bad side effects, but most ferrets have a very easy easy time with steroids and no troubles. How often a day is the med given? Pred has an 8 hour window of effectiveness, so giving it two times a day is better than once a day, and three times will hold some who can't otherwise be held. Might make sense to get one of the glucose monitors and check her levels at different times. I thihnk it's in the Trifl site where the write-up is on this though I could be wrong, but know there is stuff in the FHL archives at http://fhl.sonic-weasel.org/ . Okay, here is the info: http://fhl.sonic-weasel.org/browse.php?msg=YG11433 It's the Freestyle monitor that has been recommended and how to do it is covered there, too. [Posted in FML issue 3856]