With a history of ECE in the past, and constantly poor stools, I would think about the possiblity of inflammatory bowel disease. With this possibility, the most definitive diagnostic test available is an intestinal biopsy (either via exploratory laparotomy or endoscopy). This would be preferable to months of possibly unnecessary antibiotics. If surgery is not a possibility here, then I would recommend discontinuing the Flagyl - I see no cause to use it and the visceral reaction to this drug may result in gastric ulcers which would considerably worsen the prognosis. The use of 0.5 mg prednisone once daily for 2-4 weeks as an empiric therapy is not likely to cause any additional problems, and IBD cases are often improved on this low dose. Another thing to look at is the diet. Untreated IBD cases generally have trouble with kibbled diets, and this worsens diarrhea. A more digestible food such as baby food, duck soup, or a/d when coupled with prednisone, usually gives the most rapidly visible response. With kindest regards, Bruce Williams, DVM [Posted in FML issue 3792]