Hello, I have new used Biospot. I finally started using Frontline. Someone very knowledgeable with flea meds for ferrets told me Biospot had not been tested on ferrets. I spoke with my vet for awhile concerning Frontline. I am really funny about artificial stuff on the kids. But they had a couple of fleas. Fleas, these tiny buggers, can be transported into your abode by you walking across the grass. Fleas do not have to be transported by the furry ones to end up in the home. They just jump on anything moving or not moving. I worked at a petstore were there were pros and cons about using the frontline. But, there are pros and cons with everything. There is always an allergic reaction risk with chemicals not tested on certain animals. Just have precautionary measures ready just in case. They also have a ferret wipe that is suppose to kill fleas also. This may not have answered your question. But, I just wanted to let you know. Fleas don't discriminate on travel host. Benita [Posted in FML issue 3748]