I don't think there's any real rule about cats and ferrets. My dentist swears that his ferret killed his cat, and my secretary swears her cat unexpectedly bit her ferret (deeply, on the side/belly), and although they treated it, it died from infection. The only rule I could give you is "it depends on the cat and the ferret." Personally, I would never trust a new/adult cat with my ferrets, declawed or not, sweet or not. Why? Becuase Buttons is a little stinker who doesn't like anyone bigger than she is. Cats offend her dignity by rolling her around on the floor, and she tends to bite them for no good reason except that they were lying where she wanted to walk. However, even if she liked them, I think it's better safe than sorry. A multi-pet household is truly a lot of work. Best of luck to all Melissa [Posted in FML issue 3685]