Dear X - remember when you take out an adrenal, the excess hormones still circulate until they dissipate, and depending on the concentrations, can take up to 6-8 weeks. It likely will dissipate over time. Just because it went away quickly with the first adrenal doesn't mean it will do the same with the second one. In cases of adrenal-related pruritus (which we don't really understand), Benadryl really doesn't seem to do much. With kindest regards, Bruce Williams, DVM [Posted in FML issue 3569]