>Also, I thought the vet told us that if it's a first vaccine with a particular type of medicine, they will not react at all- that it's only the second time (and maybe subsequent shots) that you will see a reaction. Is this true? Afraid not - although it's more common to react after a second or more exposure, it is certainly possible to have a reaction the first time the animal is exposed to the substance. I would consider pre-treatment in this case. Dr. Ruth ***************************************** Save lives - spay or neuter your pet [Posted in FML issue 3567]