Since Jojo is still young (3-4 years) then surgery would be a good option. Since ADV may make the surgery a higher risk then Lupron would be a good option. Both are good choices, and it is up to you and your vet to make that tough decision. If it was my ferret, I would do adrenal surgery and use pediapred for 5-7 days after the surgery and an antibiotic (amoxi drops, or clavamox drops, or cefa drops, or Baytril) for 14 days after the surgery. Hope that helps, Jerry Murray, DVM ------------------- Well, now. Normally my recommendation for a three to four year old ferret with adrenal disease is going to be surgery, barring any other health problems. ADV is a tricky complication, because it's immunosuppressive and causes liver and kidney problems if it's active. That would of course be a bar to surgery. If it's inactive, it won't affect the surgery itself, but you have to wonder whether the stress of surgery and recovery will activate the ADV. Personally, I'd probably go the Lupron route with this little girl. JMO, of course. Dr. Ruth ***************************************** Save lives - spay or neuter your pet. [Posted in FML issue 3481]