Hi X, It sounds like you describing a perianal gland adenocarcinoma in your ferret. These are bad news. There was an article in the April 2001 issue of the vet magazine Compendium on Continuing Education that talked about treatment of this type of cancer. They used surgery and radiation therapy to manage it. Chemotherapy is also another option. Sorry I do not know about using angiogensis inhibitors in ferrets, but your vet can consult with a vet school or other cancer specialists to see if that would be useful. Hope that helps, Jerry Murray, DVM [Posted in FML issue 3470]