Lupron is safe even in the absence of hyperestrogenism. There is really no specific in-house test that your vet can run to establish the presence or absence of adrenal disease. Unlike dogs, where you can pick up some specific clues, if you want a definitive diagnosis via bloodwork, then you need to run the UT panel. There is no marker in a CBC that will identify hyperestrogenism - there are some changes that may suggest it, but none that will diagnosis it. The money is better spent getting the UT test - three Lupron injections given to a ferret that doesn't need them is far more expensive. With kindest regards, Bruce H. Williams, DVM, DACVP Join the Ferret Health List at http://groups.yahoo.com/group/Ferret-Health-list [Posted in FML issue 3452]