Dear XXXX - Increased urination is not a sign of prostatic disease. Difficulty urinating (hopping in and out of the box, or standing and straining) is. Unfortunately, the prostate is very difficult to palpate. It sits on the rim of the pelvis, a bony ridge in the normal animal. In dogs, the prostate can be felt by digital palpation, but unfortunately, ferrets are smaller than fingers (trying not to be too graphic here.) In possible cases, an ultrasound may be helpful, though. With kindest regards, Bruce H. Williams, DVM, DACVP Join the Ferret Health List at http://groups.yahoo.com/group/Ferret-Health-list [Posted in FML issue 3415]