Hi XXXXXX, Just spray 1 -2 sprays per pound on the back and sides. If you have ear mites then also spray some into the ears and on the top of the neck. Usually 1 spray per pound works just fine. The spray version of Frontline last for 30 days. Jerry Murray, DVM --------- You can use Frontline (spray or spot on) to keep the ticks off your ferrets. I do not know any product that prevents mosquito bites; however, heartworm disease is something to also worry about if you are in a high mosquito area. Jerry Murray, DVM ---------- In addition to Dr. Murray's comments, you may want to try a dilute solution of Avon's Skin-so-soft as a non-toxic way to diminish mosquito bites (both on you and your ferrets). This product has been used by animal owners for many years, while Avon was still marketing it as a humidifier for human skin. I heard that recently, they finally acknowledged its unique ability to keep mosquitoes at bay. With kindest regards, Bruce H. Williams, DVM, DACVP Join the Ferret Health List at http://groups.yahoo.com/group/Ferret-Health-list [Posted in FML issue 3404]