Sounds like you are describing an enlarged prostate secondary to an adrenal gland problem. The Lupron depot will help lower the adrenal hormones that are causing the enlarged prostate. Propecia can also be used to help shrink the prostate (ie. use both Lupron and Propecia). Flutamide can also be used to shrink the prostate, but Propecia is more specific in its mode of action and effects on the prostate. The infection can either be a simple bladder infection or a prostate infection. A prostate infection needs to be treated for a long time (1-3 months). I would use the culture and sensitivity report from the urine sample to determine which antibiotic(s) to use and use it for a long time! Yes, an urethra obstruction from the enlarged prostate will cause the BUN and Creatinine levels to be elevated (post renal azotemia) and that sounds like what was going on with Oliver. Prostate problems are frustrating but hang in there. Most will respond to Lupron, Propecia, and antibiotics (Baytril, Clavamox, etc.). Hope that helps, Jerry Murray, DVM [Posted in FML issue 3432]