A reader asked if mating would reduce adrenal symptoms in a spayed female and Brett replied: I very much doubt that mating a spayed female would reduce her estrus-like symptoms. Mating causes a whole female to ovulate; ovulation causes changes in the ovaries; and the changes in the ovaries cause them to switch from producing estrogen to producing progesterone, bringing the female out of heat. If the female is spayed and the estrogen is coming from the adrenals, then mating will not help -- you can't make an adrenal gland lay an egg. In fact, mating might even hurt, because it causes a surge of Luteinizing Hormone (LH) from the pituitary gland, and LH seems to be the hormone responsible for over- stimulating the adrenal glands in the first place. Brett [Posted in FML issue 3397]