Splenomegaly is a common finding in ferrets, and is most commonly the result of chronic inflammation, usually in the gastrointestinal tract. Around 95% of spleens are benign, and are enlarged simply by a proliferation of immature red and white blood cells in response to the circulating chemicals liberated by the chronic inflammation. Around 5% of enlarged spleens are due to tumors - with lymphoma being the most common of these. But the odds are still remarkably in your favor. Splenectomies are a common method of treating this condition, and usually have very good results. Make sure that biopsy gets sent in, though. With kindest regards, Bruce H. Williams, DVM, DACVP Join the Ferret Health List at http://groups.yahoo.com/group/Ferret-Health-list [Posted in FML issue 3397]