When Ferris had his Lupron Depot (4 month) shot it took 8 weeks before it started working. Two weeks after the shot a lump appeared on the back of his neck. Six weeks later he started growing hair, playing and feeling more relaxed. No difference in appetite for him, or activity, other than when it finally started working he wasn't fussing so much with the others. The lupron lasted about 4 months after it started working. Ferris is scheduled for his second adrenal surgery on Feb. 22 as he is again exhibiting adrenal related symptoms and prostate problems. sigh. Ferris is about 6 yrs old and in good condition, very alert and playful (well right now he is more concerned with putting ferrets away or fussing with them - grumpy), and eats well so hopefully surgery will be a breeze, recovery quick and total for him. Hugs to all. tle Troy Lynn Eckart Ferret Family Services http://www-personal.ksu.edu/~sprite/ffs.html http://www.geocities.com/Petsburgh/Haven/5481/ Please sign up to support our charity http://www.iGive.com/html/ssi.cfm?cid=46&mid=58395 [Posted in FML issue 3330]