I'm not quite sure what started the conversation but I thought I would add my two cents. I also have a ferret who had a double adrenalectomy done by a highly regarded ferret vet that most of you know of. Virtually all of her adrenal tissue was removed and she had a partial ligation of her vena cava. As Dr. Williams said, she is on hormone replacements to help her out which includes .025cc of 5mg/ml prednisone suspension daily and a pericortin injection every 6-9 weeks (we discovered she needed the injection early on when she had severe weight loss). It has been nearly two years since the surgery (she also had 1/3 of her pancreas removed at the time for insulinoma) and she is doing wonderfully well. In fact, she looks the best she has ever looked (she is 5 years old) and her blood tests have all been great. I'm certainly not suggesting that anyone jump to such drastic measures, but it can work if needed:) J. [Posted in FML issue 3299]